CD8 memory T cells: cross-reactivity and heterologous immunity

Authors

Liisa K. Selin, University of Massachusetts Medical School
Markus Cornberg, University of Massachusetts Medical School
Michael A. Brehm, University of Massachusetts Medical School
Sung-Kwon Kim, University of Massachusetts Medical School
Claudia Calcagno, University of Genoa
Dario Ghersi, University of Nebraska at OmahaFollow
Roberto Puzone
Franco Celada, University of Genoa
Raymond M. Welsh, University of Massachusetts Medical School

Document Type

Article

Publication Date

10-2004

Publication Title

Seminars in Immunology

Volume

16

Issue

5

First Page

335

Last Page

347

Abstract

Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells.

Recommended Citation

Selin, Liisa K.; Cornberg, Markus; Brehm, Michael A.; Kim, Sung-Kwon; Calcagno, Claudia; Ghersi, Dario; Puzone, Roberto; Celada, Franco; and Welsh, Raymond M., "CD8 memory T cells: cross-reactivity and heterologous immunity" (2004). Interdisciplinary Informatics Faculty Publications. 18.
https://digitalcommons.unomaha.edu/interdiscipinformaticsfacpub/18