Analysis of CAV1 Signaling in Healthy, Epithelial Cells
Advisor Information
Christine Cutucache
Location
Dr. C.C. and Mabel L. Criss Library
Presentation Type
Poster
Start Date
7-3-2014 1:00 PM
End Date
7-3-2014 4:00 PM
Abstract
Caveolin-1 (CAV1) is the major protein that comprises caveolae, also known as cave-like invaginations, that are found in both the cytoplasm and on the plasma membrane of human cells. It was once thought that CAV1 was involved solely in endocytosis; however, recent research suggests that CAV1 has multiple functions in the cell. Specifically, CAV1 is important for cell-signaling, in which it up- and down-regulates multiple cell processes; including, cell proliferation and invasion. Methods: We created an in silico model of CAV1 cell signaling in healthy, epithelial cells using primary research findings. We compared our findings with protein analysis software: STRING and BioGrid. Result: Using The Cell Collective, a mathematical computer modeling system software, we created an in silico model of CAV1 and 26 proteins that directly interact with it in healthy, epithelial cells.
Analysis of CAV1 Signaling in Healthy, Epithelial Cells
Dr. C.C. and Mabel L. Criss Library
Caveolin-1 (CAV1) is the major protein that comprises caveolae, also known as cave-like invaginations, that are found in both the cytoplasm and on the plasma membrane of human cells. It was once thought that CAV1 was involved solely in endocytosis; however, recent research suggests that CAV1 has multiple functions in the cell. Specifically, CAV1 is important for cell-signaling, in which it up- and down-regulates multiple cell processes; including, cell proliferation and invasion. Methods: We created an in silico model of CAV1 cell signaling in healthy, epithelial cells using primary research findings. We compared our findings with protein analysis software: STRING and BioGrid. Result: Using The Cell Collective, a mathematical computer modeling system software, we created an in silico model of CAV1 and 26 proteins that directly interact with it in healthy, epithelial cells.