Responses of Appetite and Appetite Regulating Hormones to Acute Altitude Exposure
Advisor Information
Dustin Slivka
Location
Dr. C.C. and Mabel L. Criss Library
Presentation Type
Poster
Start Date
4-3-2016 9:00 AM
End Date
4-3-2016 10:30 AM
Abstract
BACKGROUND: The observed loss of appetite and weight loss at high altitude may provide insight into appetite regulation. Appetite regulation has three major hormone contributors: leptin, adiponectin, and ghrelin. Leptin is a satiety hormone, signaling a “full” feeling after eating, while both adiponectin and ghrelin indicate the sensation of hunger. Exposure to altitude during mountaineering has been shown to have effects on these appetite regulating hormones. However, the results are difficult to interpret due to the physical activity associated with mountaineering also having an effect on appetite regulation. Previous research has predominately focused on chronic, free-living altitude exposure. Therefore, additional research investigating the acute response to altitude exposure on these appetite regulating hormones is warranted. PURPOSE: To determine the acute response of appetite and appetite regulating hormones after exposure to simulated altitude in resting conditions. METHODS: Twelve recreationally active males and females between the ages of 19 and 45 will be recruited. Subjects will participate in two, three-hour resting condition trials. The trials will be conducted in an environmental chamber (Darwin, St. Louis, MO) with one trial simulating 5,000 m altitude (hypoxic) and the other simulating 0 m altitude (sea level control). Blood samples from the antecubital vein will be collected prior to entering the environmental chamber and immediately following the three hours of altitude exposure. The blood samples will then be analyzed for serum leptin, adiponectin, and ghrelin concentrations via enzyme-linked immunosorbent assay kits. Subjective feelings of Acute Mountain Sickness and perceived appetite will also be assessed and analyzed.
Responses of Appetite and Appetite Regulating Hormones to Acute Altitude Exposure
Dr. C.C. and Mabel L. Criss Library
BACKGROUND: The observed loss of appetite and weight loss at high altitude may provide insight into appetite regulation. Appetite regulation has three major hormone contributors: leptin, adiponectin, and ghrelin. Leptin is a satiety hormone, signaling a “full” feeling after eating, while both adiponectin and ghrelin indicate the sensation of hunger. Exposure to altitude during mountaineering has been shown to have effects on these appetite regulating hormones. However, the results are difficult to interpret due to the physical activity associated with mountaineering also having an effect on appetite regulation. Previous research has predominately focused on chronic, free-living altitude exposure. Therefore, additional research investigating the acute response to altitude exposure on these appetite regulating hormones is warranted. PURPOSE: To determine the acute response of appetite and appetite regulating hormones after exposure to simulated altitude in resting conditions. METHODS: Twelve recreationally active males and females between the ages of 19 and 45 will be recruited. Subjects will participate in two, three-hour resting condition trials. The trials will be conducted in an environmental chamber (Darwin, St. Louis, MO) with one trial simulating 5,000 m altitude (hypoxic) and the other simulating 0 m altitude (sea level control). Blood samples from the antecubital vein will be collected prior to entering the environmental chamber and immediately following the three hours of altitude exposure. The blood samples will then be analyzed for serum leptin, adiponectin, and ghrelin concentrations via enzyme-linked immunosorbent assay kits. Subjective feelings of Acute Mountain Sickness and perceived appetite will also be assessed and analyzed.