Advisor Information
Andy Zhong
Location
Criss Library 249
Presentation Type
Oral Presentation
Start Date
2-3-2018 2:45 PM
End Date
2-3-2018 3:00 PM
Abstract
Smoothened receptor (SMO) is a protein that in humans, is encoded by the SMO gene. A systemic mutation in its binding pocket helps predict the sensitivity of mutant proteins to different drugs. Known as a GPCR-like receptor, it is a component of the hedgehog signaling pathway; a pathway involved in body patterning and the regulation of adult stem cells. An uncontrolled or inappropriate activation of the Hedgehog pathway drives tumor progression in cancers and a number of birth defects. To achieve these goals, the molecular modeling software MOE was used to build small molecules and drug molecules like Vismodegib and Sonidegib. These molecules were used for docking to the binding pocket after mutants were made through MOE also. Results however show that some of the molecules work with both the wild-type proteins and the mutants the others do not.
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Amino Acids, Peptides, and Proteins Commons, Biochemistry Commons, Biology Commons, Chemical Actions and Uses Commons, Digestive System Diseases Commons, Disease Modeling Commons, Immune System Diseases Commons, Laboratory and Basic Science Research Commons, Nursing Commons, Nutritional and Metabolic Diseases Commons, Other Life Sciences Commons, Public Health Commons, Research Methods in Life Sciences Commons, Skin and Connective Tissue Diseases Commons, Structural Biology Commons, Virus Diseases Commons
Studies of Amino Acid Mutations in Drug Resistance of the SMO Protein
Criss Library 249
Smoothened receptor (SMO) is a protein that in humans, is encoded by the SMO gene. A systemic mutation in its binding pocket helps predict the sensitivity of mutant proteins to different drugs. Known as a GPCR-like receptor, it is a component of the hedgehog signaling pathway; a pathway involved in body patterning and the regulation of adult stem cells. An uncontrolled or inappropriate activation of the Hedgehog pathway drives tumor progression in cancers and a number of birth defects. To achieve these goals, the molecular modeling software MOE was used to build small molecules and drug molecules like Vismodegib and Sonidegib. These molecules were used for docking to the binding pocket after mutants were made through MOE also. Results however show that some of the molecules work with both the wild-type proteins and the mutants the others do not.