Caveolin-1 is dispensable for early lymphoid development, but plays a role in the maintenance of the mature splenic microenvironment

Authors

Tyler Herek, University of Nebraska at OmahaFollow
Jacob E. Robinson, University of Nebraska at OmahaFollow
Tayla B. Heavican, University of Nebraska Medical Center
Catalina Amador, University of Nebraska Medical Center
Javeed Iqbl, University of Nebraska Medical Center
Christine E. Cutucache, University of Nebraska at OmahaFollow

Document Type

Article

Publication Date

2018

Publication Title

BMC Research Notes

Volume

11

Issue

470

Abstract

Objective

Caveolin-1 (CAV1) is known for its role as both a tumor suppressor and an oncogene, harboring a highly context-dependent role within a myriad of malignancies and cell types. In an immunological context, dysregulation of CAV1 expression has been shown to alter immunological signaling functions and suggests a pivotal role for CAV1 in the facilitation of proper immune responses. Nonetheless, it is still unknown how Cav1-deficiency and heterozygosity would impact the development and composition of lymphoid organs in mice. Herein, we investigated the impacts of Cav1-dysregulation on the lymphoid organs in young (12 weeks) and aged (36 weeks) Cav1+/+, Cav1+/−, and Cav1−/− mice.

Results

We observed that only Cav1-deficiency is associated with persistent splenomegaly at all timepoints. Furthermore, no differences in overall body weight were detected (and without sexual dimorphisms). Both aged Cav1+/− and Cav1−/− mice present with decreased CD19+CD22+ B cells and secondary-follicle atrophy, specifically in the spleen, compared with wild-type controls and irrespective of splenomegaly status. Consequently, the demonstrated effects on B cell homeostasis and secondary follicle characteristics prompted our investigation into follicle-derived human B-cell lymphomas. Our investigation points toward CAV1 as a dysregulated protein in follicle-derived B-cell malignancies without harboring a differential expression between more aggressive and indolent hematological malignancies.

Comments

© 2018 The authors.

https://doi.org/10.1186/s13104-018-3583-3

Recommended Citation

Herek, T.A., Robinson, J.E., Heavican, T.B. et al. Caveolin-1 is dispensable for early lymphoid development, but plays a role in the maintenance of the mature splenic microenvironment. BMC Res Notes 11, 470 (2018). https://doi.org/10.1186/s13104-018-3583-3

Creative Commons License

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