Presentation Title

Analysis of CAV1 Signaling in Healthy, Epithelial Cells

Advisor Information

Christine Cutucache

Location

Dr. C.C. and Mabel L. Criss Library

Presentation Type

Poster

Start Date

7-3-2014 1:00 PM

End Date

7-3-2014 4:00 PM

Abstract

Caveolin-1 (CAV1) is the major protein that comprises caveolae, also known as cave-like invaginations, that are found in both the cytoplasm and on the plasma membrane of human cells. It was once thought that CAV1 was involved solely in endocytosis; however, recent research suggests that CAV1 has multiple functions in the cell. Specifically, CAV1 is important for cell-signaling, in which it up- and down-regulates multiple cell processes; including, cell proliferation and invasion. Methods: We created an in silico model of CAV1 cell signaling in healthy, epithelial cells using primary research findings. We compared our findings with protein analysis software: STRING and BioGrid. Result: Using The Cell Collective, a mathematical computer modeling system software, we created an in silico model of CAV1 and 26 proteins that directly interact with it in healthy, epithelial cells.

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Mar 7th, 1:00 PM Mar 7th, 4:00 PM

Analysis of CAV1 Signaling in Healthy, Epithelial Cells

Dr. C.C. and Mabel L. Criss Library

Caveolin-1 (CAV1) is the major protein that comprises caveolae, also known as cave-like invaginations, that are found in both the cytoplasm and on the plasma membrane of human cells. It was once thought that CAV1 was involved solely in endocytosis; however, recent research suggests that CAV1 has multiple functions in the cell. Specifically, CAV1 is important for cell-signaling, in which it up- and down-regulates multiple cell processes; including, cell proliferation and invasion. Methods: We created an in silico model of CAV1 cell signaling in healthy, epithelial cells using primary research findings. We compared our findings with protein analysis software: STRING and BioGrid. Result: Using The Cell Collective, a mathematical computer modeling system software, we created an in silico model of CAV1 and 26 proteins that directly interact with it in healthy, epithelial cells.