Presentation Title

Generation of Atovaquone-Resistant Toxoplasma gondii via Chemical Mutagenesis

Advisor Information

Paul Davis

Location

UNO Criss Library, Room 232

Presentation Type

Oral Presentation

Start Date

7-3-2014 1:00 PM

End Date

7-3-2014 1:15 PM

Abstract

Toxoplasma gondii is a zoonotic protozoan parasite that is the causative agent of toxoplasmosis, a leading cause of neurological birth defects in the United States and around the world. Furthermore it is closely related to Plasmodium falciparum, the parasite that causes malaria. The research conducted was aimed at furthering understanding in drug development for these parasites through the generation of artificial drug-resistance via chemical mutagenesis of T. gondii with N-ethyl-N-nitrosurea. Through chemical mutagenesis, an atovaquone-resistant mutant strain of T. gondii was created which is now a viable positive control for further application of this technique.

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Mar 7th, 1:00 PM Mar 7th, 1:15 PM

Generation of Atovaquone-Resistant Toxoplasma gondii via Chemical Mutagenesis

UNO Criss Library, Room 232

Toxoplasma gondii is a zoonotic protozoan parasite that is the causative agent of toxoplasmosis, a leading cause of neurological birth defects in the United States and around the world. Furthermore it is closely related to Plasmodium falciparum, the parasite that causes malaria. The research conducted was aimed at furthering understanding in drug development for these parasites through the generation of artificial drug-resistance via chemical mutagenesis of T. gondii with N-ethyl-N-nitrosurea. Through chemical mutagenesis, an atovaquone-resistant mutant strain of T. gondii was created which is now a viable positive control for further application of this technique.