Presentation Title

Testing Novelty Synergistic Drug Combinations to Knock-out Toxoplasma gondii in Mice Brains

Advisor Information

Paul Davis

Location

UNO Criss Library, Room 231

Presentation Type

Oral Presentation

Start Date

6-3-2015 11:30 AM

End Date

6-3-2015 11:45 AM

Abstract

Toxoplasma gondii is an intracellular obligate parasite that is capable of invading a wide variety of vertebrates. While most infections of Toxoplasma gondii remain latent, infections can result in severe effects like behavioral changes, psychiatric disorders, and death. Currently there is no cure for the chronic infection, the bradyzoite form, of Toxoplasmosis. Prior to this study, preliminary research was performed in an attempt to develop a novel drug that will kill a chronic Toxoplasma gondii infection. Qualitative Polymerase Chain Reaction (qPCR) was performed to quantify remaining cysts in the infected mouse brains. The goal of this experiment is to determine the effectiveness of the novel drugs administered to the test subjects, hopefully leading to an identification of a novel drug combination that successfully eliminates chronic toxoplasmosis infection in mice.

Comments

Winner of Meritorious Undergraduate Oral Presentation

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COinS
 
Mar 6th, 11:30 AM Mar 6th, 11:45 AM

Testing Novelty Synergistic Drug Combinations to Knock-out Toxoplasma gondii in Mice Brains

UNO Criss Library, Room 231

Toxoplasma gondii is an intracellular obligate parasite that is capable of invading a wide variety of vertebrates. While most infections of Toxoplasma gondii remain latent, infections can result in severe effects like behavioral changes, psychiatric disorders, and death. Currently there is no cure for the chronic infection, the bradyzoite form, of Toxoplasmosis. Prior to this study, preliminary research was performed in an attempt to develop a novel drug that will kill a chronic Toxoplasma gondii infection. Qualitative Polymerase Chain Reaction (qPCR) was performed to quantify remaining cysts in the infected mouse brains. The goal of this experiment is to determine the effectiveness of the novel drugs administered to the test subjects, hopefully leading to an identification of a novel drug combination that successfully eliminates chronic toxoplasmosis infection in mice.