Presentation Title

Meta-Analysis of T-cell Leukemia/Lymphomas to Identify a Shared Gene Expression Signature

Advisor Information

Christine Cutucache

Location

Dr. C.C. and Mabel L. Criss Library

Presentation Type

Poster

Start Date

4-3-2016 12:45 PM

End Date

4-3-2016 2:15 PM

Abstract

Mature T-cell lymphomas are a heterogeneous group of malignancies representing 10-15% of all non-Hodgkin’s lymphomas with 17,850 cases diagnosed in the United States between 2003 & 2012. Mature T-cell lymphomas are characterized by having aggressive growth, generally poor clinical outcome, only a paucity of genetic abnormalities, and few mechanisms related to their tumorgenicity. Therefore, an increased effort to expand scientific knowledge in the area of T-cell lymphomas is greatly needed. Herein, we investigated gene expression data of five different mature T-cell lymphoma subtypes (n=187) and found 21 genes to be up- and down-regulated across all malignancies in comparison to healthy CD4+ and CD8+ T-cell controls (n=52). From these results, we sought to characterize a role for caveolin-1 (CAV1), a gene previously described in the progression of both solid and hematological tumors. In our analyses, CAV1 was upregulated across all mature T-cell lymphoma subtypes (in a heterogeneous nature), with tumor lymphocyte expression confirmed using immunohistochemical staining on an independent sampling of mature T-cell lymphoma biopsies (n=65 cases). Stratifying malignant samples in accordance with high and low CAV1 expression revealed that higher expression of CAV1 in mature T-cell lymphomas is correlated with a gene expression profile of a more inflammatory tumor microenvironment and that these “CAV1-High” samples may hold greater metastatic potential.

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COinS
 
Mar 4th, 12:45 PM Mar 4th, 2:15 PM

Meta-Analysis of T-cell Leukemia/Lymphomas to Identify a Shared Gene Expression Signature

Dr. C.C. and Mabel L. Criss Library

Mature T-cell lymphomas are a heterogeneous group of malignancies representing 10-15% of all non-Hodgkin’s lymphomas with 17,850 cases diagnosed in the United States between 2003 & 2012. Mature T-cell lymphomas are characterized by having aggressive growth, generally poor clinical outcome, only a paucity of genetic abnormalities, and few mechanisms related to their tumorgenicity. Therefore, an increased effort to expand scientific knowledge in the area of T-cell lymphomas is greatly needed. Herein, we investigated gene expression data of five different mature T-cell lymphoma subtypes (n=187) and found 21 genes to be up- and down-regulated across all malignancies in comparison to healthy CD4+ and CD8+ T-cell controls (n=52). From these results, we sought to characterize a role for caveolin-1 (CAV1), a gene previously described in the progression of both solid and hematological tumors. In our analyses, CAV1 was upregulated across all mature T-cell lymphoma subtypes (in a heterogeneous nature), with tumor lymphocyte expression confirmed using immunohistochemical staining on an independent sampling of mature T-cell lymphoma biopsies (n=65 cases). Stratifying malignant samples in accordance with high and low CAV1 expression revealed that higher expression of CAV1 in mature T-cell lymphomas is correlated with a gene expression profile of a more inflammatory tumor microenvironment and that these “CAV1-High” samples may hold greater metastatic potential.