Impact of acute exercise on microRNAs related to concussion symptoms

Presenter Information

Emily WorkFollow

Advisor Information

Matthew Heesch

Location

MBSC 201

Presentation Type

Poster

Start Date

6-3-2020 12:30 PM

End Date

6-3-2020 1:45 PM

Abstract

Impact of acute exercise on microRNAs related to concussion symptoms

Concussions, or traumatic brain injury (TBI), are a serious medical problem affecting approximately 1.7 million people in the United States each year. Current tools for analysis of concussion include the Glasgow Coma Scale, SCAT5, computerized topography (CT) and magnetic resonance imaging (MRI), however, these tools are typically not indicative of the range and severity of symptoms a patient may experience. Recent studies have explored the use of microRNAs as a biomarker for TBI severity in patients who have already experienced a TBI. We seek to investigate the microRNA levels in response to an exercise stimulus in a healthy population in order to establish a baseline microRNA level for a healthy population. Approximately 12 recreationally-active individuals between the ages of 19 and 45 will be recruited as participants in this study. Each participant will complete one exercise trial. Trials will consist of 1 h of cycling at room temperature at 60% of maximal power output (as established during the aerobic capacity test). 5 minutes before and 5minutes after the exercise session, blood and saliva samples will be collected. 5 mL of blood will be drawn from the antecubital vein, and saliva will be collected by having the participant expectorate into a collection tube. Expired gases will be collected during exercise for determination of exercise intensity using a flow and gas concentration calibrated metabolic cart. Data collection is planned for the summer and fall of 2020.

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Mar 6th, 12:30 PM Mar 6th, 1:45 PM

Impact of acute exercise on microRNAs related to concussion symptoms

MBSC 201

Impact of acute exercise on microRNAs related to concussion symptoms

Concussions, or traumatic brain injury (TBI), are a serious medical problem affecting approximately 1.7 million people in the United States each year. Current tools for analysis of concussion include the Glasgow Coma Scale, SCAT5, computerized topography (CT) and magnetic resonance imaging (MRI), however, these tools are typically not indicative of the range and severity of symptoms a patient may experience. Recent studies have explored the use of microRNAs as a biomarker for TBI severity in patients who have already experienced a TBI. We seek to investigate the microRNA levels in response to an exercise stimulus in a healthy population in order to establish a baseline microRNA level for a healthy population. Approximately 12 recreationally-active individuals between the ages of 19 and 45 will be recruited as participants in this study. Each participant will complete one exercise trial. Trials will consist of 1 h of cycling at room temperature at 60% of maximal power output (as established during the aerobic capacity test). 5 minutes before and 5minutes after the exercise session, blood and saliva samples will be collected. 5 mL of blood will be drawn from the antecubital vein, and saliva will be collected by having the participant expectorate into a collection tube. Expired gases will be collected during exercise for determination of exercise intensity using a flow and gas concentration calibrated metabolic cart. Data collection is planned for the summer and fall of 2020.