Presentation Title

Novel Compound to Combat Schistosoma mansoni Infection

Presenter Information

Sarah AlsuleimanFollow

Advisor Information

Dr. Paul Davis

Location

MBSC Gallery Room 308 - U

Presentation Type

Oral Presentation

Start Date

4-3-2022 10:45 AM

End Date

4-3-2022 12:00 PM

Abstract

Schistosomiasis, a commonly neglected tropical disease, is a waterborne parasitic worm infection able to infect through direct skin penetration. This disease affects approximately 270 million people worldwide and ranks only second to malaria as a leading infectious disease. Although some possible alternatives are emerging, currently, the most effective drug treatment is praziquantel (PZQ). However, PZQ is only effective against the adult stage of the worm, allowing juvenile worms to progress in the infection. Additionally, Schistosoma worms are developing resistance to this drug as reduced efficacy has been noted. Thus, the need for drug discovery and testing is increased. SA01, a worm clearing compound is being investigated to treat Schistosomiasis. Previous data points to the compound acting on the host’s immune system as opposed to directly on the worms. Single cell transcriptomics was conducted, and a notable change was significant increase in neutrophil population. To explore this immunological phenotype, transcriptomics is conducted to analyze expression patterns for genes associated with neutrophil activation and granulopoiesis to elucidate SA01’s mechanism of action.

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Mar 4th, 10:45 AM Mar 4th, 12:00 PM

Novel Compound to Combat Schistosoma mansoni Infection

MBSC Gallery Room 308 - U

Schistosomiasis, a commonly neglected tropical disease, is a waterborne parasitic worm infection able to infect through direct skin penetration. This disease affects approximately 270 million people worldwide and ranks only second to malaria as a leading infectious disease. Although some possible alternatives are emerging, currently, the most effective drug treatment is praziquantel (PZQ). However, PZQ is only effective against the adult stage of the worm, allowing juvenile worms to progress in the infection. Additionally, Schistosoma worms are developing resistance to this drug as reduced efficacy has been noted. Thus, the need for drug discovery and testing is increased. SA01, a worm clearing compound is being investigated to treat Schistosomiasis. Previous data points to the compound acting on the host’s immune system as opposed to directly on the worms. Single cell transcriptomics was conducted, and a notable change was significant increase in neutrophil population. To explore this immunological phenotype, transcriptomics is conducted to analyze expression patterns for genes associated with neutrophil activation and granulopoiesis to elucidate SA01’s mechanism of action.