Presentation Title

Characterizing the Response of Immune Cells Treated with Novel Anti-Schistosomal Compound

Presenter Information

Caleb SandallFollow

Advisor Information

Paul H. Davis

Location

MBSC Dodge Room 302B - U

Presentation Type

Oral Presentation

Start Date

4-3-2022 10:45 AM

End Date

4-3-2022 12:00 PM

Abstract

Schistosomiasis is a condition caused by a parasitic worm infection that predominantly affects third world countries. However, this parasite is currently untreatable in its juvenile form; thus, there is a clear and pressing need to develop a treatment for this affliction. There has been a novel compound developed (CS01) that has efficacy against all stages of worm infection; yet, the method of action is unknown. To characterize the response of our novel compound, we performed a series of assays to quantify how the compound affects the cellular ability to perform phagocytosis, and how this compound affects the transcriptional state of neutrophils using qPCR.

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Mar 4th, 10:45 AM Mar 4th, 12:00 PM

Characterizing the Response of Immune Cells Treated with Novel Anti-Schistosomal Compound

MBSC Dodge Room 302B - U

Schistosomiasis is a condition caused by a parasitic worm infection that predominantly affects third world countries. However, this parasite is currently untreatable in its juvenile form; thus, there is a clear and pressing need to develop a treatment for this affliction. There has been a novel compound developed (CS01) that has efficacy against all stages of worm infection; yet, the method of action is unknown. To characterize the response of our novel compound, we performed a series of assays to quantify how the compound affects the cellular ability to perform phagocytosis, and how this compound affects the transcriptional state of neutrophils using qPCR.