Presentation Title

Elucidating the Broader Antimicrobial Effects of Marinopyrrole A Against a Representative, Diverse Pathogen Panel

Presenter Information

LeeAnna LuiFollow

Advisor Information

Paul Davis

Location

MBSC Dodge Room 302A - G

Presentation Type

Oral Presentation

Start Date

4-3-2022 2:00 PM

End Date

4-3-2022 3:15 PM

Abstract

Elucidating the Broader Antimicrobial Effects of Marinopyrrole A Against a Representative, Diverse Pathogen Panel

LeeAnna M. Lui1 and Paul H. Davis

1Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE 68182

Infectious diseases are a leading cause of death globally. Being caused by over 1,400 diverse human pathogens, these pathogens are generally grouped into bacteria, fungi, protozoa, viruses and others. Despite many being treatable with clinically available antimicrobials, there exist several with limited or no treatment options. This issue and the increased burden of infectious diseases create a dire need for new antimicrobials against every human pathogen. However, individually testing against each of these pathogens would be costly and a feat. By using a developed clinically relevant, genetically diverse pathogen panel, our work explores the broader antimicrobial effects of Marinopyrrole A, a promising drug-like molecule. By screening Marinopyrrole A against a diverse set of bacteria, fungi, and protozoa, a greater understanding of its broader antimicrobial effects is gained. If successful, this study can discover new properties, like higher potency or lower toxicity, and clinical applications for Marinopyrrole A and its other analogs.

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Mar 4th, 2:00 PM Mar 4th, 3:15 PM

Elucidating the Broader Antimicrobial Effects of Marinopyrrole A Against a Representative, Diverse Pathogen Panel

MBSC Dodge Room 302A - G

Elucidating the Broader Antimicrobial Effects of Marinopyrrole A Against a Representative, Diverse Pathogen Panel

LeeAnna M. Lui1 and Paul H. Davis

1Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE 68182

Infectious diseases are a leading cause of death globally. Being caused by over 1,400 diverse human pathogens, these pathogens are generally grouped into bacteria, fungi, protozoa, viruses and others. Despite many being treatable with clinically available antimicrobials, there exist several with limited or no treatment options. This issue and the increased burden of infectious diseases create a dire need for new antimicrobials against every human pathogen. However, individually testing against each of these pathogens would be costly and a feat. By using a developed clinically relevant, genetically diverse pathogen panel, our work explores the broader antimicrobial effects of Marinopyrrole A, a promising drug-like molecule. By screening Marinopyrrole A against a diverse set of bacteria, fungi, and protozoa, a greater understanding of its broader antimicrobial effects is gained. If successful, this study can discover new properties, like higher potency or lower toxicity, and clinical applications for Marinopyrrole A and its other analogs.