Presentation Title

Assessment of left ventricular contractility in swine after thoracic endovascular aortic repair (TEVAR)

Presenter Information

Sivapriya Devidas KuniyilFollow

Advisor Information

Dr. Anastasia Desyatova

Location

MBSC Ballroom - Poster #607 - G

Presentation Type

Poster

Start Date

4-3-2022 12:30 PM

End Date

4-3-2022 1:45 PM

Abstract

Pressure-Volume (P-V) loop analysis is the gold standard in the assessment of load-dependent and load-independent measurements of the cardiac function. Dynamic measurements of the ventricular pressure and volume relation throughout a range of preload and afterload are required for load-independent measures of cardiac contractility. In the current study, the effects of thoracic endovascular aortic repair (TEVAR) on the contractility of the left ventricle (LV) were studied in a swine animal model. Animal experiments were conducted longitudinally over four months and were approved by the IACUC. N=3 animals were assigned to control and two treatment groups that resulted in different amount of aortic stiffening. LV pressure-volume relationship was measured at four months after the TEVAR using a Pressure-Volume catheter (CD Leycom, Netherlands). The catheter was calibrated using hypertonic saline and pressure-volume signals were recorded over at least 30 cardiac cycles at the baseline and during the heart challenges with dobutamine and inferior vena cava occlusion. P-V loop analysis was performed in Conduct NT by plotting pressure against volume at several time points during a single cardiac cycle. End-diastolic pressure-volume relation (EDPVR) and end-systolic pressure-volume relation (ESPVR) was calculated to analyze contractility. We found that the higher aortic stiffening after TEVAR correlated with the increased ESPVR index, suggesting that higher aortic stiffness increased the afterload of the heart which in turn increased contractility of the LV by intrinsic autoregulation mechanism (Anrep effect).

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COinS
 
Mar 4th, 12:30 PM Mar 4th, 1:45 PM

Assessment of left ventricular contractility in swine after thoracic endovascular aortic repair (TEVAR)

MBSC Ballroom - Poster #607 - G

Pressure-Volume (P-V) loop analysis is the gold standard in the assessment of load-dependent and load-independent measurements of the cardiac function. Dynamic measurements of the ventricular pressure and volume relation throughout a range of preload and afterload are required for load-independent measures of cardiac contractility. In the current study, the effects of thoracic endovascular aortic repair (TEVAR) on the contractility of the left ventricle (LV) were studied in a swine animal model. Animal experiments were conducted longitudinally over four months and were approved by the IACUC. N=3 animals were assigned to control and two treatment groups that resulted in different amount of aortic stiffening. LV pressure-volume relationship was measured at four months after the TEVAR using a Pressure-Volume catheter (CD Leycom, Netherlands). The catheter was calibrated using hypertonic saline and pressure-volume signals were recorded over at least 30 cardiac cycles at the baseline and during the heart challenges with dobutamine and inferior vena cava occlusion. P-V loop analysis was performed in Conduct NT by plotting pressure against volume at several time points during a single cardiac cycle. End-diastolic pressure-volume relation (EDPVR) and end-systolic pressure-volume relation (ESPVR) was calculated to analyze contractility. We found that the higher aortic stiffening after TEVAR correlated with the increased ESPVR index, suggesting that higher aortic stiffness increased the afterload of the heart which in turn increased contractility of the LV by intrinsic autoregulation mechanism (Anrep effect).