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The purpose of this document is to summarize and synthesize risk mitigation resources related to the opioid crisis in terms of their potential application in Nebraska, with an emphasis on health equity initiatives in the geographic region including Iowa, Missouri, Kansas, Colorado, Wyoming, and South Dakota. Exemplary resources from select other states are included and annotated, as well. Our research team sought equity-focused, evidence-based models in use regionally, as well as ancillary resources to inform Nebraska’s drug overdose prevention efforts for opioid use disorder and/or stimulant use disorder. Specifically, we searched for “evidence-based risk mitigation treatment strategies for substance use disorders” and “risk mitigation treatment strategies with a focus on equity for individuals based on race, ethnicity, gender, and socioeconomic status” as per the Drug Overdose Prevention (DOP)-STEPs work plan directed by Nebraska’s Department of Health and Human Services (NE DHHS).