Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)

Authors

Yuxiang Dong, The University of Nebraska Medical CenterFollow
Darren J. Creek, Monash University, Parkville, Victoria, Australia
Jacques Chollet, Swiss Tropical Institute, Basel
Hughes Matile, Hoffmann-La Roche, Ltd.
Susan A. Charman, Monash University, Parkville, Victoria, Australia
Sergio Wittlin, Swiss Tropical Institute, Basel
James K. Wood, University of Nebraska at OmahaFollow
Jonathan L. Vennerstrom, University of Nebraska Medical CenterFollow

Document Type

Article

Publication Date

8-2007

Publication Title

Antimicrobial Agents and Chemotherapy

Volume

51

Issue

8

First Page

3033

Last Page

3035

Abstract

Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of ironmediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron(II)-mediated activation.

Recommended Citation

Dong, Yuxiang; Creek, Darren J.; Chollet, Jacques; Matile, Hughes; Charman, Susan A.; Wittlin, Sergio; Wood, James K.; and Vennerstrom, Jonathan L., "Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)" (2007). Chemistry Faculty Publications. 20.
https://digitalcommons.unomaha.edu/chemfacpub/20