Muscle forces and power are significantly reduced during walking in patients with peripheral artery disease

Authors

Hafizur Rahman, University of Nebraska at OmahaFollow
Cody Anderson, University of Nebraska at OmahaFollow
Iraklis Pipinos, Department of Surgery, Veterans Affairs Medical Center and University of Nebraska Medical Center, Omaha, NE USAFollow
Jason Johanning, University of Nebraska Medical CenterFollow
George P. Casale
Jianghu Dong, University of Nebraska Medical CenterFollow
Holly DeSpiegelaere, Omaha and Western Iowa Veterans Affairs Medical CenterFollow
Mahdi Hassan, University of Nebraska at Omaha; VA Nebraska-Western Iowa Healthcare System
Sara A. Myers, University of Nebraska at OmahaFollow

Author ORCID Identifier

Myers - https://orcid.org/0000-0002-2934-2624

Pipinos - https://orcid.org/0000-0001-6873-6346

Dong - https://orcid.org/0000-0001-6579-7442

Document Type

Article

Publication Date

3-3-2022

Abstract

Patients with peripheral artery disease (PAD) have significantly reduced lower extremity muscle strength compared with healthy individuals as measured during isolated, single plane joint motion by isometric and isokinetic strength dynamometers. Alterations to the force contribution of muscles during walking caused by PAD are not well understood. Therefore, this study used simulations with PAD biomechanics data to understand lower extremity muscle functions in patients with PAD during walking and to compare that with healthy older individuals. A total of 12 patients with PAD and 10 age-matched healthy older controls walked across a 10-meter pathway with reflective markers on their lower limbs. Marker coordinates and ground reaction forces were recorded and exported to OpenSim software to perform gait simulations. Walking velocity, joint angles, muscle force, muscle power, and metabolic rate were calculated and compared between patients with PAD and healthy older controls. Our results suggest that patients with PAD walked slower with less hip extension during propulsion. Significant force and power reductions were observed in knee extensors during weight acceptance and in plantar flexors and hip flexors during propulsion in patients with PAD. The estimated metabolic rate of walking during stance was not different between patients with PAD and controls. This study is the first to analyze lower limb muscular responses during walking in patients with PAD using the OpenSim simulation software. The simulation results of this study identified important information about alterations to muscle force and power during walking in those with PAD.

Comments

This is an Accepted Manuscript of an article published by Elsevier in Journal of Biomechanics on March 3, 2022, available online: https://doi.org/10.1016/j.jbiomech.2022.111024

Journal Title

Journal of Biomechanics

Volume

135

Recommended Citation

Rahman H, Anderson CP, Pipinos II, Johanning JM, Casale GP, Dong J, DeSpiegelaere H, Hassan M, Myers SA. Muscle forces and power are significantly reduced during walking in patients with peripheral artery disease. Journal of Biomechanics. 135. https://doi.org/10.1016/j.jbiomech.2022.111024

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.