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What is the central question of this study?
In human arteries involved in the regulation of muscle blood flow, there is a lack of data about whether acidosis alters vascular sensitivity to vasoactive agents, as well as altering endothelium dependent vasorelaxation. Little is known about the interaction of metabolites and vascular function in human skeletal muscle feed arteries.
What is the main finding and its importance?
Increasing acidosis attenuated the response and sensitivity of the arteries to phenylephrine; this effect was selective to the receptor over smooth muscle.
Acidosis did not alter endothelium dependent vasorelaxation. Impaired vasoconstriction coupled with intact vasorelaxation, promotes decreased vascular tone with exposure to acidosis, and may contribute to sympatholysis during exercise.
Ives, S. J.; Andtbacka, R. H. I.; Noyes, R. D.; Morgan, R. Garrett; Gifford, J. R.; Park, Song-young; Symons, J. David; and Richardson, Russell S., "α1-Adrenergic responsiveness in human skeletal muscle feed arteries: the impact of reducing extracellular pH" (2012). Health and Kinesiology Faculty Publications. 78.
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