Author ORCID Identifier
Document Type
Article
Publication Date
6-24-2012
Publication Title
Acta Physiologica
Volume
206
Issue
2
First Page
135
Last Page
141
Abstract
Aim
Recently, it has been recognized that human skeletal muscle feed arteries can be harvested during exploratory surgery for melanoma. This approach provides vessels for in vitro study from a wide spectrum of relatively healthy humans. Although, the regulatory role of skeletal muscle feed arteries in rodent models has been documented, whether such vessels in humans possess this functionality is unknown.
Methods
Therefore, skeletal muscle feed arteries (~950 μm OD) from 10 humans (48 ± 4, 27–64 years) were studied using pressure myography. Vessel function was assessed using potassium chloride (KCl), phenylephrine (PE), acetylcholine (ACh) and sodium nitroprusside (SNP) concentration–response curves (CRCs) to characterize non-receptor and receptor-mediated vasoconstriction as well as endothelium-dependent and independent vasodilation respectively. To understand the physiological relevance of the diameter changes as a result of pharmacological stimulation, the estimated conductance ratio (CR) was calculated.
Results
Vessel function protocols revealed significant vasoconstriction in response to PE and KCl (35 ± 6; 43 ± 9%vasoconstriction, respectively) and significant vasodilation with ACh and SNP (85 ± 7; 121 ± 17% vasodilation, respectively). Both PE and KCl significantly reduced the CR (0.26 ± 0.05 and 0.23 ± 0.07, respectively), whereas ACh and SNP increased the CR (2.56 ± 0.10 and 5.32 ± 1.3, respectively).
Conclusion
These novel findings provide evidence that human skeletal muscle feed arteries are capable of generating significant diameter changes that would translate into significant changes in vascular conductance. Thus, human skeletal muscle feed arteries likely play a significant role in regulating vascular conductance and subsequently blood flow in vivo.
Recommended Citation
Ives, S.J., Andtbacka, R.H.I., Park, S.-.-Y., Donato, A.J., Gifford, J.R., Noyes, R.D., Lesniewski, L.A. and Richardson, R.S. (2012), Human skeletal muscle feed arteries: evidence of regulatory potential. Acta Physiol, 206: 135-141. https://doi.org/10.1111/j.1748-1716.2012.02464.x
Comments
"This is the peer reviewed version of the following article: Human skeletal muscle feed arteries: evidence of regulatory potential. Acta Physiol, which has been published in final form at https://doi.org/10.1111/j.1748-1716.2012.02464.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."