Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures

Authors

Dario Ghersi, University of Nebraska at OmahaFollow
Roberto Sanchez, Mount Sinai School of Medicine

Document Type

Article

Publication Date

7-2011

Publication Title

Journal of Structural and Functional Genomics

Volume

12

Issue

2

First Page

109

Last Page

117

Abstract

t Structural genomics projects have revealed structures for a large number of proteins of unknown function. Understanding the interactions between these proteins and their ligands would provide an initial step in their functional characterization. Binding site identification methods are a fast and cost-effective way to facilitate the characterization of functionally important protein regions. In this review we describe our recently developed methods for binding site identification in the context of existing methods. The advantage of energy-based approaches is emphasized, since they provide flexibility in the identifi- cation and characterization of different types of binding sites

Comments

The final publication is available at Springer via http://link.springer.com/article/10.1007%2Fs10969-011-9110-6.

Recommended Citation

Ghersi, Dario and Sanchez, Roberto, "Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures" (2011). Interdisciplinary Informatics Faculty Publications. 15.
https://digitalcommons.unomaha.edu/interdiscipinformaticsfacpub/15