Document Type

Article

Publication Date

3-2015

Publication Title

Journal of Pediatric Endocrinology and Metabolism

Volume

28

Issue

3-4

First Page

415

Last Page

420

Abstract

Background: Growing literature on negative childhood stress emphasizes the need to understand cortisol values from varying biomarker samples.

Objective: This work aimed to examine cortisol samples for usability, associations, and individual stability in neonates.

Subjects: The sample consisted of preterm infants (n=31).

Materials and methods: Analyses on cortisol collected from cord blood and from saliva and urine samples on days 1, 7, and 14 included Spearman correlations and paired t-tests.

Results: Usability rates were 80.6% (cord blood), 85.9% (saliva), and 93.5% (urine). Salivary and urinary cortisol levels had significant correlation on day 1 only (p=0.004). Significant differences in individual stability of cortisol concentrations existed except in urine on days 1 and 7 and in saliva on days 7 and 14.

Conclusions: Usability was highest for urine samples. We found little correlation between cortisol sample levels at each time; individual stability of cortisol concentrations was minimal. Interpretation of cortisol findings in all studies should be performed cautiously.

Comments

DOI: 10.1515/jpem-2014-0246

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