The Efficacy of KG Series Derivative for the Treatment of Toxoplasmosis

Advisor Information

Paul H. Davis

Location

Dr. C.C. and Mabel L. Criss Library

Presentation Type

Poster

Start Date

3-3-2017 10:45 AM

End Date

3-3-2017 12:00 PM

Abstract

Toxoplasma gondii is an obligate intracellular parasite that has infected nearly 60 million individuals in the United States. Acute infection of T. gondii can cause serious complications in both the immunocompromised and pregnant mothers. Current treatment options for the acute infection are limited by poor host tolerance. This research focused on the discovery and analysis of novel compounds to combat acute T. gondii infection. We found a subset of compounds to be highly effective in vitro and did not demonstrate toxic effects in a mammalian host cell battery. Further analysis included testing these novel compounds in vivo to determine their efficacy in an animal model. One compound was identified to significantly increase survivorship in an in vivo model. Further analysis and classification will be done on this compound as well as further derivatives will be synthesized.

This document is currently not available here.

COinS
 
Mar 3rd, 10:45 AM Mar 3rd, 12:00 PM

The Efficacy of KG Series Derivative for the Treatment of Toxoplasmosis

Dr. C.C. and Mabel L. Criss Library

Toxoplasma gondii is an obligate intracellular parasite that has infected nearly 60 million individuals in the United States. Acute infection of T. gondii can cause serious complications in both the immunocompromised and pregnant mothers. Current treatment options for the acute infection are limited by poor host tolerance. This research focused on the discovery and analysis of novel compounds to combat acute T. gondii infection. We found a subset of compounds to be highly effective in vitro and did not demonstrate toxic effects in a mammalian host cell battery. Further analysis included testing these novel compounds in vivo to determine their efficacy in an animal model. One compound was identified to significantly increase survivorship in an in vivo model. Further analysis and classification will be done on this compound as well as further derivatives will be synthesized.