The Efficacy of KG Series Derivative for the Treatment of Toxoplasmosis
Advisor Information
Paul H. Davis
Location
Dr. C.C. and Mabel L. Criss Library
Presentation Type
Poster
Start Date
3-3-2017 10:45 AM
End Date
3-3-2017 12:00 PM
Abstract
Toxoplasma gondii is an obligate intracellular parasite that has infected nearly 60 million individuals in the United States. Acute infection of T. gondii can cause serious complications in both the immunocompromised and pregnant mothers. Current treatment options for the acute infection are limited by poor host tolerance. This research focused on the discovery and analysis of novel compounds to combat acute T. gondii infection. We found a subset of compounds to be highly effective in vitro and did not demonstrate toxic effects in a mammalian host cell battery. Further analysis included testing these novel compounds in vivo to determine their efficacy in an animal model. One compound was identified to significantly increase survivorship in an in vivo model. Further analysis and classification will be done on this compound as well as further derivatives will be synthesized.
The Efficacy of KG Series Derivative for the Treatment of Toxoplasmosis
Dr. C.C. and Mabel L. Criss Library
Toxoplasma gondii is an obligate intracellular parasite that has infected nearly 60 million individuals in the United States. Acute infection of T. gondii can cause serious complications in both the immunocompromised and pregnant mothers. Current treatment options for the acute infection are limited by poor host tolerance. This research focused on the discovery and analysis of novel compounds to combat acute T. gondii infection. We found a subset of compounds to be highly effective in vitro and did not demonstrate toxic effects in a mammalian host cell battery. Further analysis included testing these novel compounds in vivo to determine their efficacy in an animal model. One compound was identified to significantly increase survivorship in an in vivo model. Further analysis and classification will be done on this compound as well as further derivatives will be synthesized.