Evaluating Potential Molecular Targets for Novel Anti-Toxoplasmosis Compound: KG7
Advisor Information
Paul Davis
Location
UNO Criss Library, Room 249
Presentation Type
Oral Presentation
Start Date
3-3-2017 9:30 AM
End Date
3-3-2017 9:45 AM
Abstract
Toxoplasma gondii is an intracellular obligate parasite that can infect the majority of warm-blooded animals. Although most cases of toxoplasmosis go undetected, it can cause severe disease in immunocompromised individuals and can cause congenital birth defects if a mother becomes infected while pregnant. Despite these serious possibilities, current treatment options are less than optimal due to significant side effects and cost barriers. In previous studies, compounds showing growth inhibition against Toxoplasma gondii were identified and are currently undergoing testing as promising drug candidates. Current efforts include attempting to identify a mechanism of action through the characterization of drug resistance. For the compound KG7, efforts to identify this target have yielded a target; Rhoptry Neck Protein 3, otherwise known as RON3. This protein is uncharacterized, but is thought to be important for invasion of host cells.
Evaluating Potential Molecular Targets for Novel Anti-Toxoplasmosis Compound: KG7
UNO Criss Library, Room 249
Toxoplasma gondii is an intracellular obligate parasite that can infect the majority of warm-blooded animals. Although most cases of toxoplasmosis go undetected, it can cause severe disease in immunocompromised individuals and can cause congenital birth defects if a mother becomes infected while pregnant. Despite these serious possibilities, current treatment options are less than optimal due to significant side effects and cost barriers. In previous studies, compounds showing growth inhibition against Toxoplasma gondii were identified and are currently undergoing testing as promising drug candidates. Current efforts include attempting to identify a mechanism of action through the characterization of drug resistance. For the compound KG7, efforts to identify this target have yielded a target; Rhoptry Neck Protein 3, otherwise known as RON3. This protein is uncharacterized, but is thought to be important for invasion of host cells.
Additional Information (Optional)
Winner of Best Graduate Oral Presentation