Presentation Title

Evaluating Potential Molecular Targets for Novel Anti-Toxoplasmosis Compound: KG7

Advisor Information

Paul Davis

Location

UNO Criss Library, Room 249

Presentation Type

Oral Presentation

Start Date

3-3-2017 9:30 AM

End Date

3-3-2017 9:45 AM

Abstract

Toxoplasma gondii is an intracellular obligate parasite that can infect the majority of warm-blooded animals. Although most cases of toxoplasmosis go undetected, it can cause severe disease in immunocompromised individuals and can cause congenital birth defects if a mother becomes infected while pregnant. Despite these serious possibilities, current treatment options are less than optimal due to significant side effects and cost barriers. In previous studies, compounds showing growth inhibition against Toxoplasma gondii were identified and are currently undergoing testing as promising drug candidates. Current efforts include attempting to identify a mechanism of action through the characterization of drug resistance. For the compound KG7, efforts to identify this target have yielded a target; Rhoptry Neck Protein 3, otherwise known as RON3. This protein is uncharacterized, but is thought to be important for invasion of host cells.

Comments

Winner of Best Graduate Oral Presentation

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Mar 3rd, 9:30 AM Mar 3rd, 9:45 AM

Evaluating Potential Molecular Targets for Novel Anti-Toxoplasmosis Compound: KG7

UNO Criss Library, Room 249

Toxoplasma gondii is an intracellular obligate parasite that can infect the majority of warm-blooded animals. Although most cases of toxoplasmosis go undetected, it can cause severe disease in immunocompromised individuals and can cause congenital birth defects if a mother becomes infected while pregnant. Despite these serious possibilities, current treatment options are less than optimal due to significant side effects and cost barriers. In previous studies, compounds showing growth inhibition against Toxoplasma gondii were identified and are currently undergoing testing as promising drug candidates. Current efforts include attempting to identify a mechanism of action through the characterization of drug resistance. For the compound KG7, efforts to identify this target have yielded a target; Rhoptry Neck Protein 3, otherwise known as RON3. This protein is uncharacterized, but is thought to be important for invasion of host cells.