Advisor Information
Jill Blankenship
Location
Dr. C.C. and Mabel L. Criss Library
Presentation Type
Poster
Start Date
3-3-2017 10:45 AM
End Date
3-3-2017 12:00 PM
Abstract
Candida albicans is a yeast commonly found in the gastrointestinal and genitourinary tracts of healthy individuals. Although part of the normal human microbiome, C. albicans can be problematic to certain populations such as individuals with compromised immune systems or those taking broad-spectrum antibiotics. C. albicans is the cause of diaper rash, thrush, vaginal yeast infections, and is a leading cause of systemic infections in hospitals. The focus of C. albicans research has almost entirely been focused on a single strain background, SC5314, found in clade I. This research will contribute to a larger project to delete several marker genes (URA3, LEU2, ARG4, HIS1) that are commonly used for C. albicans genetics in order to create mutant strains. These genetic tools can then be used to compare and better understand the pathogenesis and antifungal drug response across the four major clades that, along with clade I containing SC5314, cause most C. albicans infections in the United States.
Construction of Auxotrophic Strains of Candida albicans Clinical Strains
Dr. C.C. and Mabel L. Criss Library
Candida albicans is a yeast commonly found in the gastrointestinal and genitourinary tracts of healthy individuals. Although part of the normal human microbiome, C. albicans can be problematic to certain populations such as individuals with compromised immune systems or those taking broad-spectrum antibiotics. C. albicans is the cause of diaper rash, thrush, vaginal yeast infections, and is a leading cause of systemic infections in hospitals. The focus of C. albicans research has almost entirely been focused on a single strain background, SC5314, found in clade I. This research will contribute to a larger project to delete several marker genes (URA3, LEU2, ARG4, HIS1) that are commonly used for C. albicans genetics in order to create mutant strains. These genetic tools can then be used to compare and better understand the pathogenesis and antifungal drug response across the four major clades that, along with clade I containing SC5314, cause most C. albicans infections in the United States.