Advisor Information
Dustin Slivka
Location
Dr. C.C. and Mabel L. Criss Library
Presentation Type
Poster
Start Date
3-3-2017 10:45 AM
End Date
3-3-2017 12:00 PM
Abstract
Stress proteins are molecular chaperones that protect cells from the damaging effects that can be caused by exercise and environmental changes. Cold-inducible RNA binding protein (CIRP) and RNA binding motif protein 3 (RBM3) protect cells from mild hypothermia and hypoxia. They allow cells to rapidly respond to environmental stresses by regulating gene expression. Heat shock proteins 27, 70, and 90 protect skeletal tissue from exercise and heat stress. They accelerate cellular repair and prevent misfolding of proteins. These proteins, especially CIRP and RBM3, have been studied in cell cultures and animal models, but limited data exist in humans. Purpose: To determine the response of human skeletal muscle stress proteins to exercise, temperature, and hypoxia. Methods: We will analyze human skeletal muscle samples obtained during previous investigations. These studies included resting and endurance exercise in three different environmental temperatures, resistance exercise with localized temperature application, and endurance exercise with recovery in hypoxic environments. While heat shock proteins have been widely studied, very little data exists on the cold shock proteins. The data that does exist is from animal, cell culture, or surgery and do not reflect normal human physiological responses. Examining muscle biopsy samples from human participants encountering common physiological stress will add to the current understanding of stress proteins.
Human Stress Protein Response to Exercise and the Environment
Dr. C.C. and Mabel L. Criss Library
Stress proteins are molecular chaperones that protect cells from the damaging effects that can be caused by exercise and environmental changes. Cold-inducible RNA binding protein (CIRP) and RNA binding motif protein 3 (RBM3) protect cells from mild hypothermia and hypoxia. They allow cells to rapidly respond to environmental stresses by regulating gene expression. Heat shock proteins 27, 70, and 90 protect skeletal tissue from exercise and heat stress. They accelerate cellular repair and prevent misfolding of proteins. These proteins, especially CIRP and RBM3, have been studied in cell cultures and animal models, but limited data exist in humans. Purpose: To determine the response of human skeletal muscle stress proteins to exercise, temperature, and hypoxia. Methods: We will analyze human skeletal muscle samples obtained during previous investigations. These studies included resting and endurance exercise in three different environmental temperatures, resistance exercise with localized temperature application, and endurance exercise with recovery in hypoxic environments. While heat shock proteins have been widely studied, very little data exists on the cold shock proteins. The data that does exist is from animal, cell culture, or surgery and do not reflect normal human physiological responses. Examining muscle biopsy samples from human participants encountering common physiological stress will add to the current understanding of stress proteins.