Author ORCID Identifier
https://orcid.org/0000-0003-2341-4962
Advisor Information
Dr. Sara Myers
Location
University of Nebraska at Omaha
Presentation Type
Poster
Start Date
26-3-2021 12:00 AM
End Date
26-3-2021 12:00 AM
Abstract
INTRODUCTION
Peripheral Artery Disease (PAD) is characterized by atherosclerotic plaques in the leg arteries. A common treatment for PAD is supervised exercise training [1]. However, gait is not fully restored following supervised exercise training (SET). Musculoskeletal simulation may provide insight into how muscle activation changes following SET contributed to persistent gait alterations.
METHODS
Kinematic and kinetic data from overground walking of patients with PAD (n=12), before and after a 6-month exercise intervention, was used as input for musculoskeletal modeling (OpenSim). The subjects in our sample were subdivided based on the location of ischemic muscle pain, as reported on the San Diego Claudication Questionnaire. Virtual models were scaled to match the anthropometry of the subjects before muscle parameters were derived. Muscle activation was analyzed across the stance phase of gait and the output was analyzed across subjects and conditions.
RESULTS AND DISCUSSION
The subset of subjects that reported an attenuation of thigh pain as a result of SET (pain-free, n=4) showed a significant increase in late-stance knee flexor force, whereas the group that experienced no difference in thigh pain following SET (pain, n=8) did not demonstrate a significant change in knee flexor force. A significant positive association exists between the difference in absolute claudication distance and the difference in maximum knee flexor force.
CONCLUSIONS
This study demonstrated that a subset of patients with PAD experienced a significant increase in knee flexor force as a result of SET. Simulations may be an effective tool for understanding gait changes in a PAD model.
Scheduling Link
1
EFFICACY OF THE OPENSIM SIMULATOR AS A TOOL TO DETECT CHANGES IN GAIT: A PERIPHERAL ARTERY DISEASE MODEL
University of Nebraska at Omaha
INTRODUCTION
Peripheral Artery Disease (PAD) is characterized by atherosclerotic plaques in the leg arteries. A common treatment for PAD is supervised exercise training [1]. However, gait is not fully restored following supervised exercise training (SET). Musculoskeletal simulation may provide insight into how muscle activation changes following SET contributed to persistent gait alterations.
METHODS
Kinematic and kinetic data from overground walking of patients with PAD (n=12), before and after a 6-month exercise intervention, was used as input for musculoskeletal modeling (OpenSim). The subjects in our sample were subdivided based on the location of ischemic muscle pain, as reported on the San Diego Claudication Questionnaire. Virtual models were scaled to match the anthropometry of the subjects before muscle parameters were derived. Muscle activation was analyzed across the stance phase of gait and the output was analyzed across subjects and conditions.
RESULTS AND DISCUSSION
The subset of subjects that reported an attenuation of thigh pain as a result of SET (pain-free, n=4) showed a significant increase in late-stance knee flexor force, whereas the group that experienced no difference in thigh pain following SET (pain, n=8) did not demonstrate a significant change in knee flexor force. A significant positive association exists between the difference in absolute claudication distance and the difference in maximum knee flexor force.
CONCLUSIONS
This study demonstrated that a subset of patients with PAD experienced a significant increase in knee flexor force as a result of SET. Simulations may be an effective tool for understanding gait changes in a PAD model.