UNDERSTANDING THE MECHANISM OF ACTION OF AN ANTISCHISTOSOMAL COMPOUND
Advisor Information
Dr. Paul H. Davis
Presentation Type
Oral Presentation
Start Date
26-3-2021 12:00 AM
End Date
26-3-2021 12:00 AM
Abstract
As of currently, the only available treatment for schistosome parasites is praziquantel. Due to increasing resistance to the compound, it is crucial that other possible drug candidates be investigated. Fortunately, a new compound with antischistosomal activity called EE1 has proven effectiveness against both juvenile and adult worms in mice models. Yet, how the compound produces this effect is unknown. We have applied techniques to uncover hints at this anti-worm activity, including electron microscopy, ELISA, and in vitro assays. Our work suggests that the compound may function by inducing the host immune response.
Scheduling Link
1
UNDERSTANDING THE MECHANISM OF ACTION OF AN ANTISCHISTOSOMAL COMPOUND
As of currently, the only available treatment for schistosome parasites is praziquantel. Due to increasing resistance to the compound, it is crucial that other possible drug candidates be investigated. Fortunately, a new compound with antischistosomal activity called EE1 has proven effectiveness against both juvenile and adult worms in mice models. Yet, how the compound produces this effect is unknown. We have applied techniques to uncover hints at this anti-worm activity, including electron microscopy, ELISA, and in vitro assays. Our work suggests that the compound may function by inducing the host immune response.