T1 and T2 Relaxation Rates of MRI Nanosensors
Advisor Information
Ryan Riskowski
Presentation Type
Poster
Start Date
26-3-2021 12:00 AM
End Date
26-3-2021 12:00 AM
Abstract
In the past, nanobiosensors have been used for real-time tracking and intracellular monitoring, albeit only on a surface level: the techniques used thus far have relied on optical techniques, whose uses are limited by an inability to penetrate deep into bodily tissues and can therefore only be used on bodily fluids, tissue extracts, or in dermal applications. The research I have assisted Prof. Riskowski in performing over the past months has produced information regarding nanoparticle-induced T1/T2 rate alterations in an MRI and has laid the groundwork for future research into the use of nanoparticle and MRI contrast agent pairs.
This research has consisted primarily of producing gadolinium-DOTA chelates, preparing a variety of samples (mostly concentrations and mixtures of Gd-DOTA chelates and iron-oxide nanoparticles) for data collection in an MRI, analyzing the measured T1 and T2 times of said samples, and the testing of models for nanoparticle-mediated T1/T2 relaxation rate modification.
T1 and T2 Relaxation Rates of MRI Nanosensors
In the past, nanobiosensors have been used for real-time tracking and intracellular monitoring, albeit only on a surface level: the techniques used thus far have relied on optical techniques, whose uses are limited by an inability to penetrate deep into bodily tissues and can therefore only be used on bodily fluids, tissue extracts, or in dermal applications. The research I have assisted Prof. Riskowski in performing over the past months has produced information regarding nanoparticle-induced T1/T2 rate alterations in an MRI and has laid the groundwork for future research into the use of nanoparticle and MRI contrast agent pairs.
This research has consisted primarily of producing gadolinium-DOTA chelates, preparing a variety of samples (mostly concentrations and mixtures of Gd-DOTA chelates and iron-oxide nanoparticles) for data collection in an MRI, analyzing the measured T1 and T2 times of said samples, and the testing of models for nanoparticle-mediated T1/T2 relaxation rate modification.