Dietary nitrate intake improves vascular function and walking capacity in patients with peripheral artery disease
Advisor Information
Song-Young Park
Presentation Type
Oral Presentation
Start Date
26-3-2021 12:00 AM
End Date
26-3-2021 12:00 AM
Abstract
Peripheral artery disease (PAD) is an atherosclerotic vascular disease which manifests as leg pain and impaired walking capacity. Recently, nitrate supplements have been used to improve leg blood flow and exercise tolerance in PAD. However, a standard nitrate supplement protocol and mechanistic study to examine the effects of nitrate intake on oxygen delivery and utilization in the skeletal muscle of PAD has yet to be determined. Therefore, we sought to determine the impacts of a moderate dose of nitrate normalized for body mass (0.11 mmol nitrate/kg) on vascular function, skeletal muscle oxygen utilization capacity, and exercise tolerance in patients with PAD. 11 PAD patients received either the nitrate supplement or placebo in a randomized crossover design. At both visits, measures of blood pressure (BP), brachial and popliteal artery endothelial function (FMD), arterial stiffness (PWV), augmentation index (AIx), maximal walking capacity, time to claudication (COT), and skeletal muscle oxygen utility were measured pre-and-post nitrate and placebo intake. There were significant group by time interactions (pppp>0.05). These results indicate that a moderate dose of nitrate may be an effective supplement strategy for improving vascular function, oxygen utility, and walking capacity in patients with PAD.
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Dietary nitrate intake improves vascular function and walking capacity in patients with peripheral artery disease
Peripheral artery disease (PAD) is an atherosclerotic vascular disease which manifests as leg pain and impaired walking capacity. Recently, nitrate supplements have been used to improve leg blood flow and exercise tolerance in PAD. However, a standard nitrate supplement protocol and mechanistic study to examine the effects of nitrate intake on oxygen delivery and utilization in the skeletal muscle of PAD has yet to be determined. Therefore, we sought to determine the impacts of a moderate dose of nitrate normalized for body mass (0.11 mmol nitrate/kg) on vascular function, skeletal muscle oxygen utilization capacity, and exercise tolerance in patients with PAD. 11 PAD patients received either the nitrate supplement or placebo in a randomized crossover design. At both visits, measures of blood pressure (BP), brachial and popliteal artery endothelial function (FMD), arterial stiffness (PWV), augmentation index (AIx), maximal walking capacity, time to claudication (COT), and skeletal muscle oxygen utility were measured pre-and-post nitrate and placebo intake. There were significant group by time interactions (pppp>0.05). These results indicate that a moderate dose of nitrate may be an effective supplement strategy for improving vascular function, oxygen utility, and walking capacity in patients with PAD.
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