Development of a flow circuit to study the effect of Windkessel function reduction on cardiovascular hemodynamics
Advisor Information
Anastasia Desyatova
Location
MBSC Ballroom - Poster #111 - G
Presentation Type
Poster
Start Date
4-3-2022 2:00 PM
End Date
4-3-2022 3:15 PM
Abstract
The elasticity of the human aorta provides a cushioning effect called Windkessel, which protects the heart from pressure overload and maintains blood pressure and flow at a stable rate. Endovascular aortic repair is often used to treat patients with aortic trauma or degenerative aortic disease. It involves the placement of a stent-graft inside aorta in order to reconstruct blood flow to the distal organs. However, it also results in aortic stiffening and reduction of its Windessel function, which adversely affects normal hemodynamics. The role of different stent-graft factors on abnormal aorta hemodynamics is insufficiently understood. The stiffness of graft material and the aorta length covered by the stent-graft are the two factors that can play a significant role. This study aims to investigate how the type and length of the stent-graft affect flow, pressure waveforms, and pulse wave velocity. To reach this goal, a custom-made flow circuit has been built in conjunction with a pulsatile pump system to replicate human blood circulation. Aorta was approximated as a silicon tube with tuned mechanical properties to achieve pulsatility of young human aortas. Stent-grafts with different mechanical properties and lengths were deployed in these conduits resembling the human aorta and then connected to the flow circuit. Flow waveform was measured distal to the aortic conduit using a digital flow meter, and pressure waveforms were recorded proximal and distal to the conduit using digital pressure sensors. The developed flow circuit allows to analyze how the type and length of the stent-graft affect circulatory flow.
Scheduling Link
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Development of a flow circuit to study the effect of Windkessel function reduction on cardiovascular hemodynamics
MBSC Ballroom - Poster #111 - G
The elasticity of the human aorta provides a cushioning effect called Windkessel, which protects the heart from pressure overload and maintains blood pressure and flow at a stable rate. Endovascular aortic repair is often used to treat patients with aortic trauma or degenerative aortic disease. It involves the placement of a stent-graft inside aorta in order to reconstruct blood flow to the distal organs. However, it also results in aortic stiffening and reduction of its Windessel function, which adversely affects normal hemodynamics. The role of different stent-graft factors on abnormal aorta hemodynamics is insufficiently understood. The stiffness of graft material and the aorta length covered by the stent-graft are the two factors that can play a significant role. This study aims to investigate how the type and length of the stent-graft affect flow, pressure waveforms, and pulse wave velocity. To reach this goal, a custom-made flow circuit has been built in conjunction with a pulsatile pump system to replicate human blood circulation. Aorta was approximated as a silicon tube with tuned mechanical properties to achieve pulsatility of young human aortas. Stent-grafts with different mechanical properties and lengths were deployed in these conduits resembling the human aorta and then connected to the flow circuit. Flow waveform was measured distal to the aortic conduit using a digital flow meter, and pressure waveforms were recorded proximal and distal to the conduit using digital pressure sensors. The developed flow circuit allows to analyze how the type and length of the stent-graft affect circulatory flow.