Elucidating the Broader Antimicrobial Effects of Marinopyrrole A Against a Representative, Diverse Pathogen Panel
Advisor Information
Paul Davis
Location
MBSC Dodge Room 302A - G
Presentation Type
Oral Presentation
Start Date
4-3-2022 2:00 PM
End Date
4-3-2022 3:15 PM
Abstract
Elucidating the Broader Antimicrobial Effects of Marinopyrrole A Against a Representative, Diverse Pathogen Panel
LeeAnna M. Lui1 and Paul H. Davis
1Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE 68182
Infectious diseases are a leading cause of death globally. Being caused by over 1,400 diverse human pathogens, these pathogens are generally grouped into bacteria, fungi, protozoa, viruses and others. Despite many being treatable with clinically available antimicrobials, there exist several with limited or no treatment options. This issue and the increased burden of infectious diseases create a dire need for new antimicrobials against every human pathogen. However, individually testing against each of these pathogens would be costly and a feat. By using a developed clinically relevant, genetically diverse pathogen panel, our work explores the broader antimicrobial effects of Marinopyrrole A, a promising drug-like molecule. By screening Marinopyrrole A against a diverse set of bacteria, fungi, and protozoa, a greater understanding of its broader antimicrobial effects is gained. If successful, this study can discover new properties, like higher potency or lower toxicity, and clinical applications for Marinopyrrole A and its other analogs.
Scheduling Link
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Elucidating the Broader Antimicrobial Effects of Marinopyrrole A Against a Representative, Diverse Pathogen Panel
MBSC Dodge Room 302A - G
Elucidating the Broader Antimicrobial Effects of Marinopyrrole A Against a Representative, Diverse Pathogen Panel
LeeAnna M. Lui1 and Paul H. Davis
1Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE 68182
Infectious diseases are a leading cause of death globally. Being caused by over 1,400 diverse human pathogens, these pathogens are generally grouped into bacteria, fungi, protozoa, viruses and others. Despite many being treatable with clinically available antimicrobials, there exist several with limited or no treatment options. This issue and the increased burden of infectious diseases create a dire need for new antimicrobials against every human pathogen. However, individually testing against each of these pathogens would be costly and a feat. By using a developed clinically relevant, genetically diverse pathogen panel, our work explores the broader antimicrobial effects of Marinopyrrole A, a promising drug-like molecule. By screening Marinopyrrole A against a diverse set of bacteria, fungi, and protozoa, a greater understanding of its broader antimicrobial effects is gained. If successful, this study can discover new properties, like higher potency or lower toxicity, and clinical applications for Marinopyrrole A and its other analogs.