EVALUATING THE ANTI-MICROBIAL EFFECTS OF MARINOPYRROLE A ON BACTERIA SPECIES
Presenter Type
UNO Undergraduate Student
Major/Field of Study
Biology
Advisor Information
Paul H. Davis, Ph.D.
Location
CEC RM #128
Presentation Type
Oral Presentation
Start Date
22-3-2024 2:30 PM
End Date
22-3-2024 3:45 PM
Abstract
Antibiotic resistance is one of the leading causes of concern for the world health community. Drugs used to treat infections for years are now becoming easier for bacteria to resist due to mutations and plasmids conferring resistance. To combat this problem, new drug discovery can help alleviate this concern. We developed an assay that allows us to screen novel drug-like compounds against bacteria in an effort to identify promising new anti-infective compounds. Our assay was designed using known drugs against a panel of gram positive and negative bacilli and cocci. We are currently evaluating the efficacy of Marinopyrroles, which are compounds derived from marine-derived streptomycetes with limited toxicity to human cells and potential activity against bacteria. In previous publications, Marinopyrrole A has been found to have effect on gram-positive bacteria. We have found positive results against a subset of our gram-negative organisms and are continuing to test with the aim of understanding the target species range of Marinopyrrole A.
EVALUATING THE ANTI-MICROBIAL EFFECTS OF MARINOPYRROLE A ON BACTERIA SPECIES
CEC RM #128
Antibiotic resistance is one of the leading causes of concern for the world health community. Drugs used to treat infections for years are now becoming easier for bacteria to resist due to mutations and plasmids conferring resistance. To combat this problem, new drug discovery can help alleviate this concern. We developed an assay that allows us to screen novel drug-like compounds against bacteria in an effort to identify promising new anti-infective compounds. Our assay was designed using known drugs against a panel of gram positive and negative bacilli and cocci. We are currently evaluating the efficacy of Marinopyrroles, which are compounds derived from marine-derived streptomycetes with limited toxicity to human cells and potential activity against bacteria. In previous publications, Marinopyrrole A has been found to have effect on gram-positive bacteria. We have found positive results against a subset of our gram-negative organisms and are continuing to test with the aim of understanding the target species range of Marinopyrrole A.