Date of Award
Master of Arts (MA)
Dr. Bruce Chase
In the central nervous system (CNS) of insects and other invertebrates, acetylcholine (Ach) functions as a major neurotransmitter and acts upon a number of different types of receptors. One approach is to the identification of acetylcholine receptors (AChR) is to use cross-homology between vertebrate and invertebrate AChRs. To this end, monoclonal antibodies (mAbs) to the well-characterized nicotinic vertebrate AChR that cross-react with Drosophila tissues have been developed. One of them, mAb 16.42, was used to screen a lambda-ZAP expression vector library in which Drosophila adult head cDNAs were inserted, and three cDNAs that may encode nAChRs were identified.
Wu, Gang, "Characterization of cDNAs encoding potential Drosophila acetylcholine receptors." (1994). Student Work. 3343.