Impacts of Prolonged Sitting with Mild Hypercapnia on Cardiovascular Function in Healthy Adults
Advisor Information
Song-Young Park
Location
MBSC 201
Presentation Type
Poster
Start Date
6-3-2020 9:00 AM
End Date
6-3-2020 10:15 AM
Abstract
Previous research suggests that prolonged sitting attenuates vascular function. It is common for people to sit for prolonged periods of time in places such as offices and classrooms which are accompanied by mild hypercapnic conditions due to poor ventilation. However, the effects of prolonged sitting with mild hypercapnic conditions on vascular function has not been investigated.
PURPOSE: The purpose of this study is to investigate the responses in heart rate (HR), blood pressure (BP), vascular function, and autonomic function in healthy young adults to a single bout of prolonged sitting in mild hypercapnic conditions.
METHODS: In a randomized crossover design, 12 subjects (6M/6F) sat for 2.5 hours in a control condition (PSIT) or a mild hypercapnic condition (HCAP, CO2=1,500 ppm). During each visit, HR, central and peripheral BP, brachial and popliteal artery endothelial function (flow-mediated dilation, FMD), arterial stiffness (pulse-wave velocity (PWV), augmentation index (AIx)), and heart rate variability (HRV) were assessed before and after prolonged sitting.
RESULTS: Both brachial and popliteal FMD were significantly reduced (p0.05).
CONCLUSION: These results indicate that prolonged sitting in mild hypercapnic conditions attenuate endothelial function to a greater extent than prolonged sitting in normal atmospheric conditions. Our findings suggest that mild hypercapnic conditions in our daily life exacerbate the negative effects of prolonged sitting.
Impacts of Prolonged Sitting with Mild Hypercapnia on Cardiovascular Function in Healthy Adults
MBSC 201
Previous research suggests that prolonged sitting attenuates vascular function. It is common for people to sit for prolonged periods of time in places such as offices and classrooms which are accompanied by mild hypercapnic conditions due to poor ventilation. However, the effects of prolonged sitting with mild hypercapnic conditions on vascular function has not been investigated.
PURPOSE: The purpose of this study is to investigate the responses in heart rate (HR), blood pressure (BP), vascular function, and autonomic function in healthy young adults to a single bout of prolonged sitting in mild hypercapnic conditions.
METHODS: In a randomized crossover design, 12 subjects (6M/6F) sat for 2.5 hours in a control condition (PSIT) or a mild hypercapnic condition (HCAP, CO2=1,500 ppm). During each visit, HR, central and peripheral BP, brachial and popliteal artery endothelial function (flow-mediated dilation, FMD), arterial stiffness (pulse-wave velocity (PWV), augmentation index (AIx)), and heart rate variability (HRV) were assessed before and after prolonged sitting.
RESULTS: Both brachial and popliteal FMD were significantly reduced (p0.05).
CONCLUSION: These results indicate that prolonged sitting in mild hypercapnic conditions attenuate endothelial function to a greater extent than prolonged sitting in normal atmospheric conditions. Our findings suggest that mild hypercapnic conditions in our daily life exacerbate the negative effects of prolonged sitting.