Presenter Type
UNO Graduate Student (Doctoral)
Major/Field of Study
Biomechanics
Author ORCID Identifier
0000-0001-8778-4319
Advisor Information
Assistant Professor
Location
MBSC304 - G (Doctoral)
Presentation Type
Oral Presentation
Start Date
24-3-2023 10:30 AM
End Date
24-3-2023 11:45 AM
Abstract
modeling of combined twist and bending deformations of the Femoropopliteal Artery
Authors: Ali Ahmadi, Anastasia Desyatova
Peripheral arterial disease (PAD) is a narrowing or blockage of the femoropopliteal artery (FPA), leading to reduced blood flow to the downstream tissues. PAD is recognized as one of the most financially demanding vascular disorders to manage, primarily due to the high frequency of reconstruction failures that necessitate subsequent interventions. One of the reasons for the high incidence of PAD and poor treatment results can be attributed to the complex mechanical deformations that FPA experiences during routine activities. The high intramural stresses and strains that can result from severe deformations of the FPA may contribute to arterial injury and the development of diseases or restenosis following treatment. The combined impact of twisting and bending on the stresses experienced by the FPA is not fully understood so far. In the current study, a model with combined limb-flextion induced deformations was developed using flexible rings to apply twist in addition to a guiding catheter and surrounding tissues to apply bending and compression. The current computational model accurately simulated the combined deformations of the FPA that occur during the acute bent leg position. We found that the areas of strain concentration generated by bending deformations were non-uniform. Specifically, regions exhibiting acute kinks, i.e., close to the Adductor Hiatus (AH) and the popliteal artery (PA) below the knee, harbor intense stresses and strains. Furthermore, these regions are highly prone to the development of atherosclerotic disease, which implies a plausible association between elevated strains and intramural stresses, and the pathogenesis of atherosclerotic disease in the FPA.
ACKNOWLEDGEMENTS
This work was supported by the UNO Student Research and Creative Activity Fair.
Scheduling
10:45 a.m.-Noon
MODELING OF COMBINED TWIST AND BENDING DEFORMATIONS OF THE FEMOROPOPLITEAL ARTERY
MBSC304 - G (Doctoral)
modeling of combined twist and bending deformations of the Femoropopliteal Artery
Authors: Ali Ahmadi, Anastasia Desyatova
Peripheral arterial disease (PAD) is a narrowing or blockage of the femoropopliteal artery (FPA), leading to reduced blood flow to the downstream tissues. PAD is recognized as one of the most financially demanding vascular disorders to manage, primarily due to the high frequency of reconstruction failures that necessitate subsequent interventions. One of the reasons for the high incidence of PAD and poor treatment results can be attributed to the complex mechanical deformations that FPA experiences during routine activities. The high intramural stresses and strains that can result from severe deformations of the FPA may contribute to arterial injury and the development of diseases or restenosis following treatment. The combined impact of twisting and bending on the stresses experienced by the FPA is not fully understood so far. In the current study, a model with combined limb-flextion induced deformations was developed using flexible rings to apply twist in addition to a guiding catheter and surrounding tissues to apply bending and compression. The current computational model accurately simulated the combined deformations of the FPA that occur during the acute bent leg position. We found that the areas of strain concentration generated by bending deformations were non-uniform. Specifically, regions exhibiting acute kinks, i.e., close to the Adductor Hiatus (AH) and the popliteal artery (PA) below the knee, harbor intense stresses and strains. Furthermore, these regions are highly prone to the development of atherosclerotic disease, which implies a plausible association between elevated strains and intramural stresses, and the pathogenesis of atherosclerotic disease in the FPA.
ACKNOWLEDGEMENTS
This work was supported by the UNO Student Research and Creative Activity Fair.