Synthesis of Neurolysin Modulators for Stroke and Cancer Treatment
Presenter Type
UNO Undergraduate Student
Major/Field of Study
Chemistry
Advisor Information
Dr. Alan Gift
Location
MBSC Ballroom Poster # 907 - U
Presentation Type
Poster
Start Date
24-3-2023 1:00 PM
End Date
24-3-2023 2:15 PM
Abstract
Neurolysin (Nln) is a neutral metalloendopeptidase, which is an enzyme that breaks down peptide bonds in amino acids whilst ultilizing a metal catalyst. Nln inactivates several neuro/cerberotoxic neuropeptides such as neurotensin, substance P, and bradykinin. These neuropeptides can cause harm to the brain as they respond to inflammation during an ischemic stroke. The peptides generated by Nln are neuro/cerebroprotective which aid in its ability to protect the brain in an ischemic stroke victim. The goal of our lab is to discover a potent neurolysin activator in order to develop a drug that protect victims from brain damage and disability following an ischemic stroke. To begin this process, our lab successfully designed, synthesized, and established the structure-activity relationships of several potential neurolysin activators via a preliminary neurolysin activation assay on several targeted compounds. Secondary amine analogs were created and synthesized to test their neurolysin activation potential. The goals of this experiment are to resynthesize these compounds to gather additional NMR and HPLC data and to optimize the reaction to obtain a pure compound with a substantial yield.
Scheduling
9:15-10:30 a.m., 10:45 a.m.-Noon, 1-2:15 p.m., 2:30 -3:45 p.m.
Synthesis of Neurolysin Modulators for Stroke and Cancer Treatment
MBSC Ballroom Poster # 907 - U
Neurolysin (Nln) is a neutral metalloendopeptidase, which is an enzyme that breaks down peptide bonds in amino acids whilst ultilizing a metal catalyst. Nln inactivates several neuro/cerberotoxic neuropeptides such as neurotensin, substance P, and bradykinin. These neuropeptides can cause harm to the brain as they respond to inflammation during an ischemic stroke. The peptides generated by Nln are neuro/cerebroprotective which aid in its ability to protect the brain in an ischemic stroke victim. The goal of our lab is to discover a potent neurolysin activator in order to develop a drug that protect victims from brain damage and disability following an ischemic stroke. To begin this process, our lab successfully designed, synthesized, and established the structure-activity relationships of several potential neurolysin activators via a preliminary neurolysin activation assay on several targeted compounds. Secondary amine analogs were created and synthesized to test their neurolysin activation potential. The goals of this experiment are to resynthesize these compounds to gather additional NMR and HPLC data and to optimize the reaction to obtain a pure compound with a substantial yield.