Glycosaminoglycan Accumulation Increases the Susceptibility of Aortic Media to Dissection
Presenter Type
UNO Graduate Student (Doctoral)
Major/Field of Study
Biomechanics
Other
Biomechanics
Advisor Information
Anastasia Desyatova
Location
CEC RM #128
Presentation Type
Oral Presentation
Start Date
22-3-2024 10:30 AM
End Date
22-3-2024 11:45 AM
Abstract
Aortic dissection is a critical medical condition characterized by the separation of arterial inner walls, predominantly affecting the thoracic aorta. This phenomenon initiates with an initial intimal tear followed by the propagation of a crack through the medial layer, either longitudinally or circumferentially along the aorta. Despite extensive research, the precise relationship between arterial wall architecture and aortic dissection remains elusive. Glycosaminoglycans (GAGs), prominent histological features of arterial walls, are hypothesized to increase Donnan swelling pressure between elastic lamellae, potentially contributing to aortic dissection. Therefore, this study investigates the influence of GAG accumulation in the aortic media on the force required for aortic dissection. We conducted a series of 61 peeling tests on human thoracic aorta strips obtained from 35 tissue donors aged 13 to 76 years (average age 38±15, with 34% female representation). Additionally, GAG density was quantified using Movat's Pentachrome stains on the peeled sections. Our results demonstrate a significant decrease in delamination resistance (force per strip width) with age (p
Glycosaminoglycan Accumulation Increases the Susceptibility of Aortic Media to Dissection
CEC RM #128
Aortic dissection is a critical medical condition characterized by the separation of arterial inner walls, predominantly affecting the thoracic aorta. This phenomenon initiates with an initial intimal tear followed by the propagation of a crack through the medial layer, either longitudinally or circumferentially along the aorta. Despite extensive research, the precise relationship between arterial wall architecture and aortic dissection remains elusive. Glycosaminoglycans (GAGs), prominent histological features of arterial walls, are hypothesized to increase Donnan swelling pressure between elastic lamellae, potentially contributing to aortic dissection. Therefore, this study investigates the influence of GAG accumulation in the aortic media on the force required for aortic dissection. We conducted a series of 61 peeling tests on human thoracic aorta strips obtained from 35 tissue donors aged 13 to 76 years (average age 38±15, with 34% female representation). Additionally, GAG density was quantified using Movat's Pentachrome stains on the peeled sections. Our results demonstrate a significant decrease in delamination resistance (force per strip width) with age (p