Characterization of aortic physiologic strains in a swine model before and after thoracic endovascular repair using intravascular ultrasound
Presenter Type
UNO Graduate Student (Masters)
Major/Field of Study
Biomechanics
Advisor Information
Assistant Professor
Location
MBSC Ballroom Poster # 204 - G (Masters)
Presentation Type
Poster
Start Date
24-3-2023 10:30 AM
End Date
24-3-2023 11:45 AM
Abstract
Blunt thoracic aortic injury (BTAI) is one of the most common causes of mortality due to trauma incidents. Thoracic endovascular repair (TEVAR) has been increasingly used as a first-line therapy for BTAI. However, the immediate and long-term effect of the TEVAR on aortic strains is insufficiently understood. In the current study, the short and long-term effects of TEVAR on aortic strains were studied in a swine animal model. N=5 domestic swine were assigned to control and two treatment groups with different amounts of aortic stiffening. Intravascular ultrasound (IVUS) was used to evaluate aortic morphology during a cardiac cycle. IVUS measurements were collected before and after stent-graft implantation (short-term) and four months post-treatment (long-term). Aortic physiological strains were characterized in four thoracic aortic segments using cross-sectional area measurements at systole and diastole. It was found that TEVAR animals had decreased vessel strains in the stent-grafted region both short-term (77 % decrease) and long-term (77-82 % decrease) compared with control animals. Also, TEVAR animals had decreased strains distally to the stent-grafted region by 25-70 % compared with controls.
Scheduling
10:45 a.m.-Noon
Characterization of aortic physiologic strains in a swine model before and after thoracic endovascular repair using intravascular ultrasound
MBSC Ballroom Poster # 204 - G (Masters)
Blunt thoracic aortic injury (BTAI) is one of the most common causes of mortality due to trauma incidents. Thoracic endovascular repair (TEVAR) has been increasingly used as a first-line therapy for BTAI. However, the immediate and long-term effect of the TEVAR on aortic strains is insufficiently understood. In the current study, the short and long-term effects of TEVAR on aortic strains were studied in a swine animal model. N=5 domestic swine were assigned to control and two treatment groups with different amounts of aortic stiffening. Intravascular ultrasound (IVUS) was used to evaluate aortic morphology during a cardiac cycle. IVUS measurements were collected before and after stent-graft implantation (short-term) and four months post-treatment (long-term). Aortic physiological strains were characterized in four thoracic aortic segments using cross-sectional area measurements at systole and diastole. It was found that TEVAR animals had decreased vessel strains in the stent-grafted region both short-term (77 % decrease) and long-term (77-82 % decrease) compared with control animals. Also, TEVAR animals had decreased strains distally to the stent-grafted region by 25-70 % compared with controls.